The American Airlines Boeing 757-223 accident near Cali, Colombia on 20 December 1995 is an example of the possible consequences of a conflict in goals between the autoflight system and the flightcrew. The description below is from the accident report:

Aeronautica Civil of the Republic of Colombia (1996). Controlled Flight Into Terrain, American Airlines Flight 965, Boeing 757-223, N651AA, Near Cali, Colombia, December 20, 1995. Santafe de Bogota, DC, Colombia: Aeronautica Civil of the Republic of Colombia.

 At 2142 eastern standard time (est) , on December 20, 1995, American Airlines Flight 965 (AA965), a Boeing 757-223, N651AA, on a regularly scheduled passenger flight from Miami International Airport (MIA), Florida, U.S.A., to Alfonso Bonilla Aragon International Airport (SKCL), in Cali, Colombia, operating under instrument flight rules (IFR), crashed into mountainous terrain during a descent from cruise altitude in visual meteorological conditions (VMC). The accident site was near the town of Buga, 33 miles northeast of the Cali VOR (CLO). The airplane impacted at about 8,900 feet mean sea level (msl), near the summit of El Deluvio and approximately 10 miles east of Airway W3. Of the 155 passengers, 2 flightcrew members, and 6 cabincrew members on board, 4 passengers survived the accident."